Elevated A and Apolipoprotein E in A PP Transgenic Mice and Its Relationship to Amyloid Accumulation in Alzheimer’s Disease
نویسندگان
چکیده
Yu-Min Kuo, Fiona Crawford, Michael Mullan, Tyler A. Kokjohn, Mark R. Emmerling, Roy O. Weller, and Alex E. Roher Haldeman Laboratory for Alzheimer Disease Research, Sun Health Research Institute, Sun City, Arizona, U.S.A. The Roskamp Institute, University of South Florida, Tampa, Florida, U.S.A. Department of Microbiology, Midwestern University, Glendale, Arizona, U.S.A. Department of Neuroscience and Therapeutics, Parke Davis Pharmaceutical Research, Ann Arbor, Michigan, U.S.A. Department of Pathology (Neuropathology), University of Southampton School of Medicine, Southampton General Hospital, Southampton, U.K.
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Cholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
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